Enhanced dissolution profile and antihyperlipedimic. Hygroscopic stability and dissolution properties of spray. Gaud shobhaben pratapbhai patel, school of pharmacy and technology management, svkms narsee monjee institute of management studies nmims, v l mehta road, vile parle w, mumbai 400 056. Physicochemical characterization and dissolution studies. Preparation and evaluation of orodispersible tablets. Simvastatin is biopharmaceutical class 2 drug with poor oral bioavailability of 5%. So the main purpose of this investigation was to increase the solubility and dissolution rate of cefpodoxime proxetil by the preparation of its solid dispersion with urea using solvent evaporation method. Hypolipidemic activity of simvastatin solid dispersions in. The drug can be dispersed molecularly, in amorphous particles or in crystalline particles. The solid dispersion system of simvastatin with hpmc provide a promising way to improve its dissolution rate. These include particle size reduction,7 drugdendrimer conjugates,8 mesoporous carriers,9 the solid dispersion method,1012 inclusion. Solid dispersion of simvastatin for improved solubility.
Preparation of solid dispersion by solvent evaporation method. The results confirmed that the carrier molecular weight has a noticeable influence on the drug dissolution rate from solid dispersion systems. Solid dispersion of simvastatin for improved solubility, dissolution and bioavailability using modified locust bean gum. Cefpodoxime proxetil poorly water soluble drug, when prepared as solid dispersion showed improved solubility and dissolution. Carrier selection in solid dispersion is a difficult process. Rapid disintegrating tablets of simvastatin dispersions in polyoxyethylenepolypropylene block copolymer for maximized disintegration and dissolution gehan f balata,1,2 ahmad s zidan,2 mohamad as abourehab,1,3 ebtessam a essa4 1department of pharmaceutics, faculty of pharmacy, umm alqura university, makkah, saudi arabia. The aim of the present study was to improve the solubility and dissolution rate of a poorly water.
Simvastatin dissolution rate was markedly improved in the form of solid dispersion using pegs as hydrophilic carriers. The aim of this work was to improve the aqueous solubility of simvastatin using the surface solid dispersion. Structural insight into the physical stability of amorphous. The effect of the addition of polymeric wetting agents namely peg6000, pluronic f68, myrj 52 and pvp k30 to. The aim of the present study was to improve solubility, dissolution rate and antihyperlipedimic activity of sim using solid dispersion with pluronic f68. D3 1department of quality assurance techniques, 2department of pharmaceutics, 3department of pharmaceutics, vjsms vishal institute of pharmaceutical education and research, ale, pune, maharashtra.
Preparation and characterization of solid dispersion of simvastatin article in drug development and industrial pharmacy 3611. The aim of this study was to prepare solid dispersions sd of sim with inert carriers in an attempt to improve the release profile. Among all the methods, solid dispersion has been widely used to increase oral bioavailability, solubility and dissolution rate of the drug. Choudhary a, rana ac, aggarwal g, kumar v, zakir f.
Atorvastatin solid dispersion for bioavailability enhancement. Solid lipid nanoparticles of simvastatin for improved oral delivery solid lipid nanoparticles have been increasingly utilised for improving oral bioavailability of drugs. Pdf preparation and characterization of solid dispersion tablet of. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug. The objective of the present study was to formulate surface solid dispersions ssd of simvastatin to improve the aqueous solubility and dissolution rate to. Formulation and evaluation of simvastatin solid dispersion. Rapid disintegrating tablets of simvastatin dispersions in. To obtain free flowing, stable, amorphous solid dispersions sds of simvastatin sim, a drug with relatively lower glass transition temperature t g by spray drying technique, and to perform comparative in vivo study in rats, which could justify the improvement in rate and extent of in vitro drug release.
Pdf dissolution improvement of simvastatin by surface solid. Fast disintegrating crystalline solid dispersions of. Water soluble mannitol and lactose and insoluble avecil ph101 carriers were used. In the case of simvastatin, solid dispersions prepared with either pvp or peg exhibited the largest improvement in wettability and dissolution rate. Ir spectra of pure drug simvastatin, and optimized solid dispersion of simvastatin were obtained which shows all the characteristic peaks of simvastatin and carrier was present in the solid dispersion, thus indicating no significant evidence of chemical interaction between drug and carrier, which confirms the stability of drug with its solid. Pdf dissolution improvement of simvastatin by surface. Dissolution tests were performed in distilled water and artificial intestinal fluid using the usp paddle ii method. The required amount of simvastatin and hpmc were dissolved in ethanol 96 % with the aid of stirring until clear solution was formed. Simvastatin by microwave generated solid dispersion techniques. Dsc and ftir indicated the formation of solid dispersion without chemical interaction between simvastatin and polymer. Effect of carriers on solid dispersions of simvastatin sim.
Dissolution improvement of simvastatin by surface solid dispersion. Simvastatin solid lipid nanoparticles for oral delivery. Enhancement of solubility and dissolution rate of simvastatin by ternary solid dispersion technique shete reshma s. Polyvinylpyrrolidone pvp and polyethylene glycol peg are the most widely used polymers for the preparation of solid dispersions. Formulation and evaluation of extended release solid dispersions conatining simvastatin prasad tandale, dipti joshi, r. As demonstrated by a range of dsc, xrpd, raman and ssnmr experiments, including fluorescence analysis in raman spectra, simvastatin was found to form nanosized clusters of approximately 23 nm dispersed in the rigid, glassy phpma matrix. Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Dissolution enhancement of aceclofenac tablet by solid.
Dissolution improvement of simvastatin by surface solid dispersion technology. Simvastatin is poorly bioavailable because it is practically insoluble in water and shows dissolution ratelimited absorption. Then, solid dispersion based tablets containing 20 mg simvastatin were prepared with excipients. The effect of peg molecular weights on dissolution behavior.
Dissolution improvement of simvastatin by surface solid. The solid dispersions in different wv ratio were prepared by solvent evaporation method. The purpose of this research was to formulate and characterize solid dispersion sd of simvastatin using polyethylene glycol 4000 as the hydrophilic carrier and methocel k15m as the release retardant by the solvent evaporation and cogrinding method. The sd formulation in addition, the thermal behaviors of sfn powder. Solid dispersions were formulated using soybean powder as polymer in different ratios. Preparation and characterization of solid dispersion of. Spray dried solid dispersion sdp of crystalline simvastatin sim in a fast disintegrating matrix of superdisintegrants was studied as a method to enhance sim dispersibility, rheology, compactibility and compressibility for incorporation into orodispersible tablets odts. The present study involved preparation of solid dispersions of simvastatin to improve the aqueous solubility and dissolution rate in order to facilitate faster onset of action.
The dissolution rate of simvastatin from solid dispersion increased with an increased ratio of hpmc polymer. Preparation and characterization of simvastatin solid dispersion. Pdf preparation and characterization of solid dispersion. Formulation and evaluation of extended release solid. The term solid dispersion refers to a grou p of solid products consisting of at least two differe nt components, generally a hydrophilic matrix and a hydrophobic drug.
Enhanced dissolution profile and antihyperlipedimic activity of simvastatin by solid dispersion with pluronic f68 authors. Spraydried amorphous solid dispersions of simvastatin, a low. Then the solvent was allowed to evaporate completely. Pdf characterization of solid dispersions of simvastatin. Simvastatin, poor water solubility, surface solid dispersion. Characterization was performed by fourier transform. Solubility enhancement of poorly water soluble drug simvastatin by.
Solid dispersion of simvastatin in starch phosphate was formulated by solvent evaporation technique. The aim of this study was to obtain a stable, amorphous solid dispersion sd with soluplus, prepared by hotmelt extrusion hme as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly watersoluble simvastatin sim, a drug with relatively low tg. Cd on simvastatin in aqueous solution were investigated using the phase solubility technique. A new type of completely amorphous solid dispersion of simvastatin molecules in phpma was prepared. Enhanced dissolution profile and antihyperlipedimic activity.
Formulation, evaluation, simvastatin, dispersion 1. Enhancement of solubility and dissolution of atorvastatin by solid dispersion technique with novel carriers a. Preparation and characterization of solid dispersion of simvastatin. Preparation and characterization of simvastatin solid dispersion using aqueous solvent 243 j. Pdf enhancement of solubility and dissolution rate of.
In this research different batches were prepared by using the. Accurately weighed carrier corresponding to different drug. K p v o o solubility augmentation of simvastatin by using. Preparation and characterization of simvastatin solid. Enhancement of simvastatin dissolution by surface solid dispersion. Enhancement of simvastatin dissolution by surface solid. Increase in dissolution rate of simvastatin by amorphous. Enhancement of solubility and dissolution rate of simvastatin. Nevertheless, it is a problematic and inefficient route of delivery. Abstract the purpose of the present study was to investigate the effect of polyethylene glycol peg molecular weights 6000, 12000 and 20000 as solid dispersion sd carriers on the dissolution behavior of simvastatin. Pdf preparation and characterization of solid dispersion of.
We investigated the influence of sas process parameters pressure, temperature, and solute concentration on the formation of ezetimibehpc solid dispersion particles. The dissolution profiles of the solid dispersions were measured in a ph 6. Development and characterization of an atorvastatin solid dispersion formulation using skimmed milk for improved oral bioavailability. Shyam sunder 3 1dept of pharmaceutical sciences, ouct, osmania university, hyderabad500007, telangana, india. Enhancement of solubility and dissolution rate of simvastatin by ternary solid dispersion technique. The aim of this work was to improve the aqueous solubility of simvastatin using the surface solid dispersion ssd technique. Kwang hyeon kim, junbom park, wonjae choi, han seung lee.
Enhancement of solubility and dissolution of atorvastatin by. The influence of drug polymer ratio on drug release was studied by dissolution testing. Simvastatin solid dispersion system was prepared by solvent technique using hpmc as carrier with ratios of 1. May 25, 2015 enhancement of solubility and dissolution rate of simvastatin by ternary solid dispersion technique. Introduction the term solid dispersion refers to a group of solid products. Oct 12, 2015 the purpose of the present study was to fabricate ezetimibehydroxypropyl cellulose hpc solid dispersion nanoparticles with enhanced dissolution and oral bioavailability using the supercritical antisolvent sas process.